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Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent
Giannini G, Soldi S, Elli M, et al
( F ) Mean GSH/GSSG ratios in A549shNRF2-BIND-luc, -BIND-WT NRF2, -BIND-Neh4/5mut cells treated with water (control) or 2.5 ng/mL dox for 48 h
It was shown that the toxicity of OTA could be decreased by maintaining glutathione production with N-acetyl cysteine (NAC), which decreased reactive oxygen species (ROS) and 8-oxoguanine formation
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