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Bibcode:2011FEBSL.585.1651K
Research has shown that GLP-1 receptor agonists can promote the formation of cyclic adenosine monophosphate in thyroid C cells, increasing serum calcitonin synthesis and release, which may lead to the occurrence of thyroid C cell carcinoma
In multiple pathological settings, affected cells are not distributed randomly, but instead form contiguous zones of degeneration, synchronized tubular epithelial loss, aligned myofiber injury, or expanding fronts of tissue damage, patterns that are difficult to reconcile with strictly cell-autonomous execution
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