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Abbreviations AE: Adverse event BMI: Body mass index BP: Blood pressure CI: Confidence interval CV: Cardiovascular CVOT: Cardiovascular outcome trial DBP: Diastolic blood pressure ETD: Estimated treatment difference GIP: Glucose-dependent insulinotropic polypeptide GLP-1 RA: Glucagon-like peptide-1 receptor agonist HbA1c: Glycated haemoglobin A1c MACE-4: Major adverse cardiovascular events proAND: Pro-atrial natriuretic peptide SBP: Systolic blood pressure T2D: Type 2 diabetes WL-D: Weight-loss dependent WL-IND: Weight-loss independent References Petrie JR, Guzik TJ, Touyz RM