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A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*28 alleleHowever, the precise dose reduction in this patient population is not known 43 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Other polymorphisms of UGT due to random genetic differences have been reported, but only a few have suggested to influence drug metabolism in the clinic.e.g

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The lysate was clarified using centrifugation and split into two fractions

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This discovery is particularly notable as previous studies have already implicated WWP-1 as an important mediator of lifespan extension by dietary restriction 96,97