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eLife 4 , e06253 (2015)
Adenosine has multiple physiological effects both within the central nervous system and on peripheral tissues that are mediated by the G-protein coupled adenosine receptors identified as A 1 , A 2A , A 2B , and A 3
The transport capability of MSNs at the sizes of 20, 40, and 80 nm were evaluated by the authors and were calculated to be 44.0%, 59.2%, and 38.6%, respectively, which were all higher than that of free drugs (32.8%), indicating a size-dependent penetration mechanism
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