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If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks
Diabetes Care 1996
However, restoration of acute myocardial blood flow can pose a risk to cardiomyocytes, resulting in reperfusion injury and a notable impact on infarct size and prognosis [96]
It has been reported to cause vomiting, diarrhea, a fishy body odor, abdominal cramps, and nausea
Furthermore, it was stated that clinicians must consider treating patients with T2D and NAFLD with PIO, GLP-1R agonists or sodium-glucose co-transporters 2 (SGLT2) inhibitors to reduce their significant cardiovascular risk
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