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The STEP trial program demonstrated substantial weight reductions with many participants achieving losses approaching those seen with metabolic surgery
For example, a meta-analysis of 31 randomized, controlled trials reports that the most common side effects observed in the hGH studies and their respective incidences were [16]: Soft tissue edema: 50% Insulin resistance: 22% Arthralgias: 21% Carpal tunnel syndrome: 19% These side effects are transient and usually subside as the patient gets used to the therapy
In the STEP 9 trial, once-weekly semaglutide in adults with obesity and moderate-to-severe KOA was associated with significantly greater weight loss and greater improvement in knee pain than placebo at 68 weeks (Bliddal et al., 2024)
Since Saxenda frequently causes similar side effectsespecially during the initial titration periodcombining these medications may result in more pronounced gastrointestinal symptoms
They were so concerned that they staged an intervention
