The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks
Dipeptidyl peptidase-4 is widely expressed across various organs and bodily fluids, including the biliary tract (24), kidneys (25), gastrointestinal tract (26), lungs (27), uterus (28), liver (29-32), and immune cells such as T cells, activated natural killer (NK) cells, and activated cells (33-36)
This is an excerpt from our February 2026 Pharmacy Essential Updates continuing education webinar series
However, some users may experience side effects, which typically resolve on their own or with dose adjustment: If any side effects occur, reducing the dose or temporarily discontinuing use is usually effective
Yes, acetaminophen (Tylenol) does deplete glutathione, your body's primary antioxidant and detoxification molecule