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This, in part, may account for the higher affinity of exendin-4 for the isolated receptor ECD and the higher affinity of amino terminally truncated exendin-4 peptides, where exendin(9-39) displays only 10-30-fold lower affinity compared to exendin-4, relative to the equivalent GLP-1(15-36), which has greater than 300-fold lower affinity than GLP-1 22, 31
It remains potent for 60-90 days when properly stored
Experts say that, based on current evidence, we cannot say for sure that probiotics promote weight loss
The bottom line: Zepbound users typically see somewhat greater weight loss on average, but both medications deliver meaningful results
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