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Inflammation: Chronic, low-grade inflammation accelerates aging and contributes to disease

J Clin Invest (2000) 105:136371

Chiang said: It is interesting that our study did not show a reduction in cancer risk with GLP-1 receptor agonist use when previous observational studies have demonstrated beneficial effects of these treatments in cancer prevention/reduction in cancer risk. However, he stressed that the discrepancy likely stems from the fact that these are two different types of study designrandomized controlled trial data in our case which is typically less susceptible to confounding bias due to randomization versus observational data in these previous studies which are susceptible to confounding bias due to the lack of randomization. Chiang continued: When comparing GLP-1 receptor agonist groups with non-GLP-1 receptor agonist groups, there are often inherent differences between the two that are hard to adjust or control for in observational studies

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Mazdutide, targeting GLP-1 and glucagon (but not GIP), reaches about 14-20% weight loss depending on dose and trial duration