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This review sets out the molecular and central nervous system biology of the GLP-1 receptor, the mechanisms proposed to underlie its neuroprotective effects, and the clinical trial record in Parkinsons and Alzheimers disease

At the index date in GLP-1 RA vs SGLT-2 inhibitor cohort, GLP-1 RA users were generally younger (median age 55 years [25-75 percentile: 45-65] vs 66 years [25-75 percentile: 57-74] more often female (59% vs 36%) and had a higher level of education compared with SGLT-2 inhibitor users (21% vs 15% were within ISCED level 6-8)

Actual semaglutide for human use, as furnished by Novo Nordisk, is produced by first engineering yeast cells to make the underlying peptide

That human review is a key reason appeals can succeed