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Topical calcineurin inhibitors are regarded as safe for short-term or intermittent long-term use, although they are generally less effective than corticosteroids

If the cell cannot recycle GSSG back into GSH fast enough using an enzyme called glutathione reductase, the cell enters a state of toxic oxidative stress, leading to mitochondrial damage and, eventually, programmed cell death (apoptosis)

In practice, the schedule is a guide rather than a rigid timetable

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