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Patients with certain health issues might need their doses adjusted to avoid problems

Fasting insulin and HOMA-IR (a measure of insulin resistance) decreased substantially at all active doses, with the greatest reductions at 8mg and 12mg

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[Crossref] Pawlak AL, Strauss E (2001) Polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) and incidence of hyperhomocysteinemia-related diseases

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