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[18] Gene-expression profiling shows it upregulates collagen types I, III, and IV and suppresses MMPs, mirroring retinol's effects via separate mechanisms

Cephalalgia 21(6):643655 Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR (2018) Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

Another possible mechanism involves the drug's effects on the sympathetic nervous system the part of your body that controls stress responses which could tighten blood vessels and cut off circulation to delicate eye tissue

This breakdown covers both therapies from a clinical perspective so you can have an informed conversation with your provider

Fuchs and Warner, 1975