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MOTS-c activates AMPK in myocyte and hepatocyte cultures, modeling enhanced glucose uptake and lipid oxidation

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Demonstrated by chick chorioallantoic membrane (CAM) and endothelial tube formation assays, both in vivo and in vitro, BPC 157 was shown to increase both vessel density and accelerate the recovery of blood flow in ischemic muscle, indicating a promotional effect on angiogenesis