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IBS-C patients had lower serum GLP-1 levels, which was connected with abdominal pain, indicating GLP-1s potential for alleviating pain in these patients
However, it seems that long-term L-carnitine intake eventually converts to a metabolite called trimethylamine N-oxide (TMAO) (9799), and increased circulating levels of this metabolite can increase the prevalence of diabetes (54% per 5 mol/L increment of plasma TMAO) (100), nonetheless one study showed that increased TMAO plasma level by 30 mol/L after 24 weeks of L-carnitine supplementation was not related to glucose, insulin and HOMA-IR levels changes (97)
The views expressed or information supplied through this article is mere opinion and observation of the author
Verma, F
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death
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