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Pickart stated that GHK-Cu has a favorable safety profile, highlighting that there is no indication that it causes side effects in test subjects [2]: The molecule is very safe and no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies. In a 2018 review based on new genetic data, he reiterated that all biological actions associated with GHK appear to be health positive. He pointed to over four decades of GHK research encompassing cell, tissue, and animal studies, also noting the peptides inclusion in commercial anti-aging and cosmetic products such as creams, liposomes, and dermal patches [1]

An intramuscular injection skips the digestive system entirely

Some people notice subtle shifts, perhaps slightly easier sleep onset or marginally improved morning alertness, but many notice nothing at all

FDA.gov

Cheng, F., Wang, Q., Chen, M., Quiocho, F