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These findings are further supported by another sub-analysis of SURMOUNT1, which reported a 33.9% (8.2% for placebo) reduction in fat mass and a 10.9% (2.6% for placebo) reduction in lean mass by week 72, with approximately 75% of weight loss attributable to fat mass, consistent across clinically relevant subgroups [68]

Distinguished Professor Emeritus Department of Nutrition and School of Medicine University of California, Davis Copyright 2000-2026 Linus Pauling Institute Figure Alternative Text Figure 1

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