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As research progresses, the hope is that some of these biologic modalities will enter clinical practice, especially in high-stakes surgeries (transplantation, cardiac surgery, major trauma) where current supportive care is not always sufficient to prevent organ injury
PMID: 3169264 Simon A, Wegrowski Y, Bontemps Y, Maquart FX
[1] If you experience persistent or concerning symptoms after starting B12 supplements, particularly skin changes or gastrointestinal issues, it is advisable to discuss these with your GP rather than assuming they are directly caused by vitamin excess
Consequently, BCL-2 family inhibitors have been identified to function as senolytics, including ABT-737, ABT-263 (Navitoclax), A-1331852, and A-1155463
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