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GLP-1 makes it easier to stay full

doi: 10.1016/j.biopha.2018.03.031 99 BarbieriFBosioAGPattarozziATonelliMBajettoAVerduciIet al

So it was a twice-a-day shot, which barely cleared the hurdle of good enough to be a drug, but we made it into a drug along with our partner Amylin and launched that in 2006

Tirzepatide requires careful dose escalation (starting at 2.5 mg weekly, advancing to 5, 7.5, 10, or 15 mg) over 16+ weeks to minimize gastrointestinal side effects

Dopamine is also impacted