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GIP receptor activity contributes additional incretin signalling and is studied in relation to adipose function

Gjermeni E, Kirstein AS, Kolbig F, Kirchhof M, Bundalian L, Katzmann JL, Laufs U, Blher M, Garten A, Le Duc D (2021) ObesityAn update on the Basic Pathophysiology and Review of recent therapeutic advances

Histone acetylation is an enzyme-catalysed posttranslational modification that results in a functional alteration in gene transcription in the acetylated histone region

Measurable weight change often appears by 6 to 12 weeks, with greater change over months

My overarching issue with Arrae as a company is that they seem to make claims about their products that are not supported by solid, peer-reviewed, human trials