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at China Pharmaceutical University and Nanjing First Hospital: oral Dihexa restored spatial learning and memory in the APP/PS1 transgenic mouse model of Alzheimers disease via the PI3K/AKT signaling pathway, reduced neuroinflammation, and preserved hippocampal synaptophysin expression (Sun et al., Brain Sciences 2021)
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Week 5 to 8: For weekly formulations, steady-state drug concentrations are achieved, and the first dose escalation typically occurs around week 4 or 5
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