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Most people take their last semaglutide dose, wait one week, then start tirzepatide at an appropriate dose based on their previous semaglutide level

In MASLD, GLP-1RAs and co-agonists (GLP-1/GIP or GLP-1/glucagon) have shown efficacy in reducing hepatic fat, improving fibrosis, and resolving steatohepatitis, with promising results from trials such as ESSENCE and SYNERGY-NASH

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Diabetologia 40 , 984986 (1997)