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Both are likely to require either significant real world observation in off-label use, or some form of RCT with careful observation
Duration of Use Phentermine is intended for short-term use, typically up to 12 weeks, as its effectiveness can diminish over time, and prolonged use can lead to dependence
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However, tirzepatide treatment restored the levels of PDX1, MAFA and ALDH1A3 (Fig
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