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vehicle-injected PNA mice, which displayed clear signs of altered cyclicity, denoted by the presence of only one generation of corpora lutea, frequently corresponding to persistent regressing corpora lutea, indicative of occasional ovulations

Clin Imaging 34:382384 Nishio S, Morioka T, Murakami N et al (1999) Melanotic neuroectodermal tumour of infancy at the anterior fontanelle

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However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia