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Coverage is more common among larger organizations, with approximately 43% of employers with 5,000 or more workers offering weight-loss coverage in their largest health plan

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The increased gallstone risk may be attributable to two mechanisms: the rapid and substantial weight loss these medications facilitate, and potentially direct effects of GLP-1 agonists on reducing gallbladder motility and emptying

This macrocyclic constraint restricts conformational flexibility, contributing to the extended biological activity duration observed versus native -MSH