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Larger changes (5+ letters, visual field changes exceeding test-retest variability, OCT thickness changes over 5-10 microns) more clinically relevant

Other studies in ApoE / mice demonstrated that TMAO repressed hepatic bile acid synthesis by inhibiting Cyp7a1 expression in the classical pathway of bile acid synthesis and that this inhibition might be mediated by activation of the nuclear receptor FXR and small heterodimer partner (SHP), thus accelerating the formation of aortic AS (Makishima et al., 1999

Could affect oral birth control: Since GLP-1 medications can slow digestion, they may affect how oral birth control pills are absorbed

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All animal studies were approved by the State of Bavaria, Germany, or the Insitutional Animal Care and Use Committee of the University of Cincinnati, OH, USA and conducted on the basis of the underlying animal welfare law of the respective countries