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They likely reflect the difference between pathological IGF-1 excess (which does appear to increase cancer risk and accelerate ageing in some models) and normalisation of IGF-1 in individuals whose levels have declined below an optimal physiological range due to somatopause

doi: 10.1523/JNEUROSCI.0039-11.2011 208 WilliamsL

(Silver Spring) 28 (6), 10501061 (2020) M

That scenario falls well within the 21-day, sub-86-degree window

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