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Designed for adults with obesity, it provides the same benefits as injectable GLP-1s but in pill form

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All other standard laboratory chemicals or culture reagents were obtained from Sigma or Thermo Fisher unless otherwise specified

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The binding of insulin with IR causes autophosphorylation of IR [20, 21], activating downstream phosphoinositide-3-kinase (PI3-K)/Akt and mitogen activated protein kinase (MAPK) pathways, which affect the differentiation, energy metabolism and activity of osteocytes [22, 23]

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