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Compared with unexposed pregnancies, the GLP-1 RA-exposed group had a higher risk for excess gestational weight gain (risk ratio, 1.32), greater mean birth weight percentile (58.4 versus 54.8 percent), and a higher risk for preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy (risk ratios, 1.34, 1.30, and 1.29, respectively)

They also reported that LC supplementation causes increased oxidative activity of mitochondria in the resultant MII oocytes without increasing the ATP levels in MII oocytes [55]

DHEA levels decline with age

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For example, while the SUSTAIN-6 study included patients with proliferative DR (PDR) and diabetic macular edema (DME), other CVOTs, such as PIONEER 6, did not