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Furthermore, GLP-1 RAs play a pivotal role in the alleviation of oxidative stress, the maintenance of mitochondrial homeostasis, and the inhibition of cell apoptosis and pyroptosis in models of ischemic cardiomyopathy [16]
Semaglutide acts on GLP-1 alone
Cold-turkey discontinuation is generally not advised unless medically necessary
At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems
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