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In recent years, a growing number of methods for p53-based therapy, such as the use of small molecules that can inhibit the interaction between p53 and its negative regulators, mouse double minute 2/4 (MDM2/4), small molecules that can reactivate the function of mutant p53, and drugs that target specific types of p53 mutants, have emerged

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Brettschneider J, Lehmensiek V, Mogel H, Pfeifle M, Dorst J, Hendrich C, Ludolph AC, Tumani H