Medicating the environment
Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD et al
With these parameter values, model simulations are performed to collect information on an outcome of interest, which can be the model output or another outcome, and finally a PRCC is calculated for each input factor
Thus, all three of the main UA transporters may contribute to the brain concentrations of UA through their action at the blood-brain barrier, although ABCG2 is thought to have the greatest effect, probably acting to remove UA from brain to blood 45
Figure 6 displays the PRCC output with [GSH]/[GSSG] ratio at PN28 as outcome of interest for the control C3H mice and the RP rd1 mice