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Refrigerating unopened vials extends shelf life even further

Now be aware that like any drug, there is also a chance of side effects, and people should be aware that they may increase the chance to develop severe nausea, abdominal pain, diarrhea, acute pancreatitis (which is an inflammation of the pancreas), and rarely cancers

Body composition matters more than the number on the scale

Measure hematologic parameters annually and vitamin B12 at 2 to 3 year intervals and manage any abnormalities

A gradual step-down gives the researcher time to implement dietary and behavioral strategies at each lower dose level, building habits that can partially compensate for the loss of pharmacological support