Greater weight loss during treatment was associated with greater rebound, suggesting biological adaptations, potentially involving changes in appetite hormones, metabolism, or reward sensitivitythat increase susceptibility to weight regain [141]
Although oral Semaglutide offers a non-injectable dosing option, it faces a number of challenges, notably bioavailability, metabolic stability, and gastrointestinal side effects (Ke et al., 2024) (Table 2)
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Convenience of Use Tirzepatide is administered via a once-weekly injection, similar to Semaglutide
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