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This metabolite not only traverses the BBB to inhibit A aggregation via direct interaction but also facilitates A clearance mediated by microglia through the ApoE-TREM2 signaling pathway [205]

Further it is known that the gut microbiome is involved in the synthesis of neurotransmitters such as glutamate, serotonin, noradrenaline, dopamine and gamma aminobutyric acid (GABA) and their functions and bioavailability both in the central nervous system and in the periphery

Botch is a -Glutamyl cyclotransferase that deglycinates and antagonizes notch

MK-677 is the only oral compound on this list