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& Monne, M
What the Clinical Data Actually Shows The most definitive comparison comes from the SURMOUNT-5 trial, a direct head-to-head study published in the New England Journal of Medicine comparing tirzepatide 10 mg and 15 mg against semaglutide 2.4 mg in adults with obesity but without diabetes
Inflammatory bowel disease during active flares GI side effects can be hard to distinguish from disease activity, and tolerability can be lower during flares
Rheumatology (Oxford) 64, 3085-3089 (2025)
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