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In addition, deletion of Alk3 from the tubular epithelium resulted in enhanced fibrosis and reduced renal function after exposure to nephrotoxic serum, demonstrating a protective role for Alk3-mediated signaling in the kidney
Originally developed for type 2 diabetes, these treatments are now widely used for weight loss, PCOS, and insulin resistance
This also pinpointed when glutathione is specifically required: during the early steps of metastatic colonization, when cancer cells adapt rapidly to the stressful environment of a new tissue
A follow-up study from Guo et al
The team, led by graduate fellow Nicole DelGaudio and postdoctoral fellow Hsi-wen Yeh, then analyzed the metabolites in these organelles to reveal how mitochondrial metabolites shift when cancer cells colonize new sites
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