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Note that the solutions of the sensitivity differential equations are vectors of values over the time interval we consider (PN11 through PN28, expressed in minutes), so in calculating the normalized local sensitivity coefficients (shown in Fig

Research demonstrates that copper-binding peptides including GHK-Cu suppress the NF-B pathway through direct molecular interactions, with nuclear translocation of NF-B p65 decreased by approximately 30% upon treatment and molecular modeling showing specific peptide sequences exhibit high binding affinity to NF-B p65 (up to -8.8 kcal/mol)

doi: 10.1038/s41589-020-0613-y 51 KoppulaPZhuangLGanB

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