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1990 Mar;51(1):67-80
Effect of Saxagliptin on renal outcomes in the SAVOR-TIMI 53 trial
It works alongside sodium to maintain fluid balance, helps produce stomach acid for digestion, and assists in carbon dioxide transport
Diabetes indications are often treated differently from obesity indications
three other compounds have been approved in Japan (Ipragliflozin, Tofogliflozin, Luseogliflozin), while others are in development (Ertugliflozin and Sotagliflozin) ( Canagliflozin Canagliflozin [(1 S )-1,5-andro-1-[3-[[5-(4-fluorophenyl)-2-tienil]metil]-4-metilfenil]-d- GLUCITOLO emirate], is a C-glycosyl compound that is used (in the hemihydrate form) for the treatment of T2DM through inhibition of sodium/glucose co-transporter 2 ( It was initially approved by the FDA in 2013 for the management of T2DM and later approved in 2018 for a second indication of reducing the risk of cardiovascular events in patients diagnosed with T2DM
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