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The trans-3-hexenoic acid group sterically shields the N-terminal region from dipeptidyl peptidase IV (DPP-IV) cleavage, which is the primary route of GHRH degradation in vivo, resulting in meaningfully improved metabolic stability compared to native GHRH and sermorelin
Older people tend to have lower amounts of stomach acid, which the body needs to absorb B12
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