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NICE recommends GLP-1 receptor agonists for type 2 diabetes when metformin and other oral medications fail to achieve adequate glycaemic control, particularly with BMI 35 kg/m or weight-related comorbidities

The half-life of caffeine the time it takes to eliminate half of the substance from the body is around 5 hours, meaning its stimulating effects can persist for several hours

But it does mean that side effects during the first week or two of a dose increase are not necessarily representative of what that dose feels like at steady state

Formation of hydrogen peroxide was followed as the increase of DCF fluorescence (Cathcart et al, 1983