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Tirzepatide (Dual GIP/GLP-1 Agonist) Tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors: GLP-1 effects same appetite suppression and insulin sensitivity as semaglutide GIP receptor activation enhances fat metabolism and insulin secretion through a complementary pathway Synergistic signaling the dual mechanism produces greater metabolic effects than either pathway alone This dual agonism is why Tirzepatide has shown superior weight loss in head-to-head trials