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This effect is believed to be due to IGF-1 suppression of insulin secretion, which leads to augmented lipolysis in adipose tissue and promotion of FFA use by muscle
For this reason, it is no longer just a marker of risk but actively contributes to the mechanism itself
Interactions with pre-existing conditions
Multiple Sclerosis and Related Disorders 36: 101395
Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide
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