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Tirzepatide showed higher average weight loss in SURMOUNT trials, while semaglutide has a very large GLP-1 evidence base

Acknowledgements This work was supported by the National Key Research and Development Program of China No

Additionally, these medications enhance insulin secretion in a glucose-dependent manner and suppress glucagon release, contributing to improved glycemic control in patients with type 2 diabetes

doi: 10.1080/10255842.2015.1018193 15

APD-elevated glucagon may therefore drive the hyperglycemic states that these drugs produce since glucagon receptor KO mice are protected against APD-induced hyperglycemia independently of changes in insulin levels 21