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Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), vegans and vegetarians, people with pernicious anaemia or gastrointestinal disorders affecting absorption, and those taking certain medications such as metformin or proton pump inhibitors

doi: 10.1074/jbc.M112.448050 96 ChinisazMLarijaniBEbrahim-HabibiA

Combining them into one blend means one reconstitution, one draw, and one injection instead of four which is the entire practical appeal

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In the context of pharmaceutics, an ideal training set includes a diversity of protein sequences, CDR sequences and lengths, protein attributes (mixed charged and hydrophobic molecules), and solution conditions (diversity of excipients, pH, and ionic strength)