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The 6-month and 12-month cohorts were treated independently, so that any given individual could be included in either cohort, or in both, provided they had data available at the relevant time points

severe cases may require re-amputation at higher level Stump necrosis: Surgical revision, debridement, skin grafting if sufficient viable tissue

Innovating to expand access at lower costs Cost is one of the main reasons patients put off getting started or stop their treatmenteven when its working

Studies suggest improvements in blood pressure , cholesterol , sleep quality , mental clarity , and gut health

As a result, weight loss tends to be more gradual