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Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and bloodbrain barrier penetrationusing DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entryloaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function

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Conversely, miR-193b-3p, which targets 5-LOX, exerts neuroprotective effects in I/R injury, identifying it as a potential therapeutic target (141, 142)

What BPC-157 does at the tissue level is promote angiogenesis, the formation of new blood vessels into damaged tissue, and it activates growth hormone receptors in tendon fibroblasts, which accelerates collagen synthesis at the repair site

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