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Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (41)
Glutathione disulfide can be converted back to glutathione by glutathione reductase, in a reaction that consumes NADPH
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