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In skeletally mature female rats, moderate energy restriction over 12 weeks had minimal negative effects on bone, but severe restriction significantly reduced bone mass and levels of IGF-1, leptin, and estradiol

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Patient safety advice includes staying well-hydrated, reporting persistent gastrointestinal symptoms, and seeking urgent medical attention for severe abdominal pain, signs of dehydration, or symptoms of lactic acidosis (muscle pain, breathing difficulties, unusual tiredness)

Your healthcare provider can help determine whether medications may be influencing your results

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